Purified anti-HCN4 Antibody, HCN4, N114-10,BioLegend,857001

Hyperpolarization activated cyclic nucleotide gated ion channel 4 (HCN4) is a subunit of a total 4 HCN protein family that carries inward current with the feature knows as Ifin the heart and Ihin the brain. These currents have been indicated in a wide array of physiological activities, including pacemaker activity of neurons, and cardiomyocytes, control of resting membrane potential, neuronal plasticity, dendrite formation and response to sour taste.  Although widely expressed in the central nervous system, HCN4 is enriched in regions regulating mood and anxiety including thalamus, amygdala, midbrain dopamine system, and indirectly prefrontal cortex. SNP genotyping indicates the association of HCN4 with mood anxiety disorders. In cardiomycates, HCN4 is required for pacemaker potential generation. Mice lacking HCN4 globally or in cadiomyocytes are embryonic lethal.