Purified anti-HSF1 Antibody anti-HSF1 - 4B4,BioLegend,825801

Host

Rat

Reactivity

Human, Mouse

Application

IHC-P -Quality testedWB, ICC -Reported in the literature, not verified in house

Platform ID

BAB373166525

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePurified anti-HSF1 Antibody anti-HSF1 - 4B4
Cat. No.825801
HostRat
RRIDAB_2564892 (BioLegend Cat. No. 825801)
IsotypeRat IgG2a, κ
ReactivityHuman, Mouse
ApplicationIHC-P -Quality testedWB, ICC -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone Number4B4
Concentration1 mg/mL
TargetHSF1
ImmunogenThis monoclonal antibody was raised against mouse recombinant HSF-1 protein and was mapped to amino acids 425-439.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution.
StorageThis antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label orCoAto find the proper storage conditions.
Regulatory StatusResearch Use Only

Scientific Background

HSF1 is a DNA-binding protein that exists as an inactive monomer in a complex with Hsp40/Hsp70 and Hsp90.  Upon stress, HSF1 is released from the chaperone complex and trimerizes.  HSF1 is then transported into the nucleus where it is hyperphosphorylated and binds to DNA containing heat shock elements (HSE) and activates transcription of proteins such as HSP70.  HSP70 is known to inhibit the tau and alpha synuclein aggregation seen in Alzheimer’s Disease and Parkinson’s Disease.

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