Purified anti-Hippocalcin Antibody, Hippocalcin, A18228E,BioLegend,619251

Hippocalcin, a member of the neuronal calcium (Ca2+) sensor family, is a Ca2+-binding protein that translocates between membrane and cytosol through its Ca2+/myristoyl switch. Its structural composition consists of 191 amino acids, forming a compact protein with a molecular weight of approximately 21 kD. The protein is characterized by the presence of four EF-hand motifs, each containing a helix-loop-helix structure, facilitating high-affinity Ca2+binding. Through its Ca2+-sensing capabilities, hippocalcin modulates various crucial cellular functions and signaling pathways. It participates in the regulation of intracellular Ca2+homeostasis and influences Ca2+-dependent signaling cascades. The protein's interactions with key proteins and enzymes enables it to contribute to processes such as neurotransmitter release, synaptic plasticity, and neuronal excitability. Hippocalcin’s involvement in human diseases has been observed in several conditions. In neurological disorders like epilepsy, dysregulation of hippocalcin disrupts Ca2+signaling, leading to neuronal hyperexcitability and the manifestation of seizures. Additionally, alterations in hippocalcin expression and function have been linked to neurodegenerative diseases, including Alzheimer's and Parkinson's, suggesting its potential role in disease progression. Furthermore, elevated levels of hippocalcin have been associated with certain cancers, such as breast and lung cancer, indicating its involvement in tumor progression and metastasis.