Purified anti-IKKgamma NEMO Antibody anti-IKKgamma - W16070A,BioLegend,694101

NF-kB represents a family of transcription factors that are normally inactive in the cytoplasm by binding inhibitory molecules of the IkB proteins. In response to various stimuli such as: inflammatory cytokines, bacterial or viral products, or various types of stress, the IkB proteins become phosphorylated by Iκ B kinase (IKK) complex. This leads to the polyubiquitination and destruction by the proteasome. Consequently, free NF-kB enters the nucleus and activates transcription of a variety of genes involved in immune and inflammatory response, cell adhesion, growth control, and inhibition of apoptosis. The IKK complex consists of the regulatory subunit IKKγ/NEMO (NF-κ B Essential Modifier) and two catalytic subunits (IKKα and IKKβ). IKKγ is an adaptor protein involved in activation of the IKK kinases and has been shown to be essential for the canonical and stress-induced NF-κ B pathway. Recently, Medunjanin S, et al reported that GSK-3β is critically important for ordered NF-κB signaling through modulation of IKKγ phosphorylation.