Purified anti-ILK Antibody anti-ILK - P83A9,BioLegend,694902

Integrin-linked kinase (ILK) is an integrin associated actin and tubulin cytoskeletal interacting effector. ILK was identified in a search for proteins interacting with integrin β CTs. It has an N-terminal ankyrin repeat domain (ARD) and a C-terminal integrin β CT binding kinase-like domain (KLD). ILK functions as a key scaffold at cell-ECM adhesions and regulates integrin-mediated as well as growth factor regulated functions. ILK orchestrates several signaling pathways, such as PI3Kinase/Akt, Wnt, TGF-β, Hippo tumor suppressor pathway and epithelial-mesenchymal transition signaling in various types of cancer cells. ILK expression is upregulated in many types of cancers.