Purified anti-MAFB Antibody anti-MAFB - O91E9,BioLegend,692302

MAFB belongs to the Maf transcription factor family, the members of which contain basic leucine zipper (bZIP) domains that bind to DNA. These bZIP domains are located within the Maf recognition element (MARE) and regulate the transcription by binding to acidic domains within the target genes. MAFB plays roles in differentiation processes, including the differentiation of macrophage, pancreatic alpha and beta cells, podocytes in the renal glomerulus, and rhombomeres in the embryonic brain. MAFB is also central to embryonic thymus development, parathyroid gland development, the creation of hair cuticles, and urethral masculinization. In the hematopoietic system, MAFB is important for myeloid lineage commitment of hematopoietic stem cells. MAFB was recently reported to have features of oncogene. It was viewed as a sensitive and specific marker for poor prognosis in multiple myeloma patients. Silencing of MAFB inhibited migration and invasion of nasopharyngeal carcinoma cells. In liver cancer, MAFB promotes cancer cell proliferation by transcriptionally targeting Cyclin D1.