Purified anti-MAVS Antibody, MAVS, W21144C,BioLegend,624351

Mitochondrial antiviral signaling protein (MAVS) is essential and specific for innate immunity by activating IRF3, IRF7 and NF-κB in response to viral infection. MAVS is located on the outer membranes of mitochondria, peroxisomes, and mitochondria-associated endoplasmic reticulum membranes (MAM). The MAVS protein contains an N-terminal CARD domain and a C-terminal mitochondrial transmembrane domain. MAVS acts downstream of the RIG-I RNA helicase and sensing viral RNA, leading to the recruitment of IKKε, TRIF and TRAF6. Some viruses have developed strategies to evade these innate defense mechanisms by using proteases that cleave MAVS and prevent its localization to mitochondria. The C-terminal region of MAVS cleavage by the hepatitis C virus (HCV) protease allows HCV to evade the host immune system.