Purified anti-METTL14 Antibody, METTL14, W18219A,BioLegend,669602
While this clone is able to immunoprecipitate METTL14 from whole cell extracts, the resulting fraction was not significantly enriched in METTL14; therefore, this clone may not be suitable for detecting transient or low-abundance complexes.
Host
Rat
Reactivity
Human, Mouse
Application
WB -Quality testedIP -Verified
Platform ID
BAB081827584
BioLegend
Contact
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Product Specifications
Scientific Background
Specifications
NamePurified anti-METTL14 Antibody, METTL14, W18219A
Cat. No.669602
HostRat
RRIDAB_2814512 (BioLegend Cat. No. 669601)AB_2814513 (BioLegend Cat. No. 669602)
IsotypeRat IgG2a, κ
ReactivityHuman, Mouse
ApplicationWB -Quality testedIP -Verified
ClonalityMonoclonal
Clone NumberW18219A
Concentration0.5 mg/ml
TargetMETTL14
ImmunogenPartial-length recombinant human METTL14 protein between 1-300 a.a.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
METTL14 forms a heterodimer with METTL3 called the m6A-methyltransferase complex (MTC) to methylate adenosine residues at the N6 position of eukaryotic mRNAs. MTC-induced methylation takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs. In the MTC complex, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate. Once methylated, the mRNAs are recognized by distinct proteins known as “readers” that will affect their stability, splicing, and/or translation.
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