Purified anti-MOG Antibody, MOG, A24108A,BioLegend,648881

Myelin oligodendrocyte glycoprotein (MOG) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. This heavily N-glycosylated protein features a single extracellular immunoglobulin-like domain, a transmembrane region, and a short intracellular tail. MOG is expressed on the surface of oligodendrocytes in the outermost layer of myelin and is highly conserved across species. MOG plays a critical role in the completion and maintenance of the myelin sheath, possibly acting as a cell adhesion molecule that contributes to myelin integrity and immune regulation. MOG is notably implicated in a group of autoimmune demyelinating disorders collectively known as MOG antibody-associated disease (MOGAD). In these conditions, the immune system produces antibodies targeting MOG, leading to inflammation and damage in the optic nerves, spinal cord, and brain.