Purified anti-PAX6 Antibody, W19167A,BioLegend,939801

Paired box protein 6 (PAX6) is a transcription factor with dual roles as both transcriptional activator and repressor. It plays a critical role in the regulation of cell proliferation, cell cycle length and exit, and cell differentiation during neurogenesis and ocular, cortical, and olfactory development. PAX6 forms a complex with SOX2 and δ-crystallinenhancer DC5 to initiate lens placode development. In the central nervous system, PAX6 functions in the regulation of progenitor cell proliferation, telencephalic patterning, cortical layer formation, and the maintenance of balance in neuron differentiation.   Heterozygous mutations inPAX6can result in aniridia, nystagmus, neurodevelopmental disorders, and auditory and memory impairment. In the neuroendocrine system, PAX6 functions in the development of β cells, pancreatic islet of Langerhans cells, and the pituitary gland as well as in insulin biosynthesis, and glucose-induced insulin secretion. PAX6 functions as a tumor suppressor in prostate cancer and glioblastoma by inhibiting androgen receptors.