Purified anti-PER1 Antibody, PER1, W17208B,BioLegend,936001

PER1 (Period Circadian Regulator 1), a transcriptional repressor, is a component of the circadian clock and a member of the Period family. The circadian clock is the body’s internal time keeping mechanism, which regulates various physiological processes including hormone rhythms, locomotor activity, sleep cycle, and behavior. PER1 is expressed throughout peripheral tissues but expression is most significant in the suprachiasmatic nucleus (SCN) region of the brain which functions as the primary circadian pacemaker in mammals. PER1 is expressed in an oscillating rhythm with a period of about 24 hours which is maintained even in constant darkness. PER1 expression is light dependent, with exposure to light during subjective night increasing expression and shifting its phase in the SCN. Full length PER1 localizes to the cytoplasm with a shorter nuclear isoform localizing in the nucleus. Diseases associated with PER1 include periodic limb movement disorder (PLMD), advanced sleep phase syndrome, cardiovascular diseases and cancer.