Purified anti-RPS6KA1 Antibody, RSK1, 6B9-D6-F8,BioLegend,602551

Ribosomal protein S6 kinase α1 (RPS6KA1), most commonly known as RSK1, is a serine/threonine kinase that acts downstream of ERK/MAPK signaling. Upon activation, RSK1 translocates to the nucleus where it controls the activity of several important transcription factors, such as CREB1 and c-FOS. Additionally, RSK1 directly controls translation through phosphorylation of the transcriptional protein RPS6 and EIF4B. Through these roles, RSK1 is involved in the control of cellular growth and proliferation, and genetic variants of RSK1 have been implicated in multiple cancer types.