Purified anti-RSK1 Phospho (Ser380) Antibody, RSK1 Phospho (Ser380), A23014F,BioLegend,692151

RSK1 (ribosomal S6 kinase 1) is a serine/threonine kinase that plays a pivotal role in various cellular processes, including cell growth, survival, and proliferation. It is activated by the ERK/MAPK signaling pathway and subsequently phosphorylates a range of substrates involved in transcription, translation, and cell cycle regulation. RSK1 is particularly important in cancer biology, where its aberrant activation is linked to the progression of several malignancies, including breast, prostate, and lung cancers. Additionally, RSK1 is implicated in cardiovascular diseases and inflammatory responses. Phosphorylation at serine 380 is crucial for RSK1 full activation. This modification creates a docking site for PDK1, which further phosphorylates RSK1, leading to its complete activation and enabling it to phosphorylate downstream targets. Dysregulation of this phosphorylation event can disrupt normal cellular functions and contribute to disease pathogenesis.