Purified anti-RhoA Antibody, RhoA, A18230D,BioLegend,635851

RhoA, also known as Transforming protein RhoA, is a small GTPase that plays a crucial role in various cellular functions, such as cytoskeletal dynamics, cell migration, cell cycle regulation, and cellular development. It alternates between active and inactive states by binding to either GTP or GDP, respectively. It is primarily associated with the regulation of the cytoskeleton, particularly in the formation of actin stress fibers and actomyosin contractility. RhoA influences cell shape, polarity, and locomotion through its effects on actin organization. In human mesenchymal stem cells, RhoA activity switches the differentiation between adipogenesis or osteogenesis under actin-myosin-generated cytoskeletal tension via effector, Rho-kinases (ROCK). RhoA is essential for cleavage furrow formation and apical junctions in keratinocyte cell-cell adhesion. In the developing nervous system, p75NTR induces RhoA strengthening on actin assembly which limits growth cone mobility and neuronal elongation. RhoA is found overexpressed or hyperactivate in many types of cancers, including prostate cancer, gastric cancer, testis cancer, breast cancer, and chronic myeloid leukemia. A RhoA inhibitor targeting RhoA/Rho GTPase pathway aims to prevent breast cancer cell growth as a potential cancer drug.