Purified anti-Runx3 Antibody anti-Runx3 - R3-5G4,BioLegend,697902

This antibody recognizes the two isoforms of Runx3 with predicted molecular weights of 44.4 and 45.9 kD.This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).

Host

Mouse

Reactivity

Human

Application

WB -Quality testedIP -Verified

Platform ID

BAB708450569

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-Runx3 Antibody anti-Runx3 - R3-5G4
Cat. No.697902
HostMouse
RRIDAB_2687206 (BioLegend Cat. No. 697901)AB_2687207 (BioLegend Cat. No. 697902)
IsotypeMouse IgG1
ReactivityHuman
ApplicationWB -Quality testedIP -Verified
ClonalityMonoclonal
Clone NumberR3-5G4
Concentration0.5 mg/ml
TargetRunx3
ImmunogenPurified recombinant fragment of human Runx3 (aa: 187-234).
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

The runt related transcription factor (Runx3) is a downstream effector of the TGF-β signaling axis, and has been shown to play a critical function in cancer metastasis through transcriptional control of genes involved in apoptosis, cell signaling, cell migration, and invasion. Additionally, Runx3 plays an essential role in differentiation of CD8 and NK cells. Runx3 forms a heterodimer with the CBFβ subunit. The Runx3-CBFβ complex binds to the core sequence 5'-PYGPYGGT-3' found in enhancer and promoter regions of its target genes, where it can either induce or suppress gene expression. Evidence suggests Runx3 functions as a tumor suppressor in many cancers.

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