Purified anti-S100B Antibody anti-S100B - 11C12E12,BioLegend,676603

S100B is glial-specific. It has been shown that it is only expressed by a subtype of mature astrocytes that ensheath blood vessels, and by NG2-expressing cells. This protein may function in neurite extension, stimulation of Ca2+fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. In the developing central nervous system (CNS), it acts as a neurotrophic factor and neuronal survival protein. In the adult organism, it is usually elevated due to nervous system damage, which makes it a potential clinical marker. S100B is secreted by astrocytes or can spill from injured cells and enter the extracellular space or bloodstream. Serum levels of S100B increase in patients during the acute phase of brain damage. Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood–brain barrier (BBB) permeability and central nervous system injury.