Purified anti-SHP-2 Phospho (Tyr542), SHP-2 Phospho (Tyr542) Antibody, A22019A,BioLegend,651751

SHP-2 is encoded by the PTPN11 gene, is a well-known oncogenic member of the protein tyrosine phosphatase (PTP) family. SHP-2 regulates cellular functions by dephosphorylating targets downstream of PD1, EGFRvIII, HGF receptor, and cytokine receptors. Cellular processes controlled by SHP-2 include mitotic cycle, cell growth, differentiation, and oncogenesis. Phosphorylation of tyrosine 542 and 580 of SHP-2 in response to growth factor receptor activation leads to a stimulation in its tyrosine phosphatase activity. SHP-2 has been recognized as a potential therapeutic target for cancers including breast cancer, lung cancer, leukemia, gastric cancer, and oral cancer.