Purified anti-SIRT5 Antibody anti-SIRT5 - O91G9,BioLegend,698801

The seven mammalian Sirtuin isoforms are assigned to different Sirtuin classes on the basis of sequence homology. The mitochondrial SIRT5 belongs to class III. In the mitochondrial matrix, Sirt5 deacetylates and activates carbamoyl phosphate synthetase 1 (CPS1), which is increased when amino acid metabolism is upregulated during fasting. More importantly, SIRT5 regulates lysine succinylation and malonylation as evolutionarily conserved post-translation modifications. SIRT5 was proved to regulate many metabolic pathways, with fatty acid beta-oxidation and ketone body production as two pathways strongly enriched in lysine succinylation. Recently, Zhang et al demonstrated that SIRT5 was targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin in order to promote respiratory chain function.