Purified anti-SKP1 Antibody, SKP1, P84E11C10,BioLegend,605651

S-Phase Kinase Associated Protein 1 (SKP1) is one of the core components of the Skp, Cullin, F-box containing (SCF) E3 ubiquitin ligase complex which poly-ubiquitinates protein targets for proteasomal degradation, and thereby regulates a variety of cellular processes including DNA damage response, apoptosis, cell cycle, and overall genome stability. Within the SCF, SKP1 serves as an adaptor protein linking the scaffolding protein Cul1 to F-box proteins. Beyond its role as part of SCF, SKP1 also functions in centrosome organization, chromosome segregation, meiotic progression, and oocyte survival. Aberrant SKP1 expression is associated with chromosomal misalignment and instability, disrupted cell cycle, and is a characteristic of several cancers.