Purified anti-SLC1A5 Antibody, SLC1A5, W19125A,BioLegend,608051

Solute carrier family 1 member 5 (SLC1A5 or ASCT2) belongs to the SLC1 transporter family, which is used for exchanging neutral amino acids, especially glutamine uptake. SLC1A5 on the cytosolic membrane transports glutamine inwardly to regulate cellular energy metabolism, biosynthesis, cell proliferation, and signal transduction. In hematopoietic stem cells, SLC1A5 is necessary for erythroid cell differentiation. During placenta development, SLC1A5 serves as the receptor of syncytin-1 to stimulate trophoblast syncytialization. SLC1A5 is highly expressed in multiple cancers by positively regulating c-Myc, mTOR, and MAPK-PI3K signaling pathways to support tumor cell chemoresistance and cell growth. In addition, an SLC1A5 isoform variant induced by HIF-2α is expressed in mitochondria, that enhances metabolism and promotes drug resistance.