Purified anti-SMAD1 Phospho S463S465SMAD9 S465/S467 Antibody, SMAD1 Phospho, SMAD9 Phospho, A17019A,BioLegend,610402
Because the sequence of the synthetic phosphopeptide immunogen is completely conserved between SMAD1 and the corresponding residues in SMAD9 (Ser465/Ser467), this clone is predicted to recognize both phosphorylated proteins.This clone is predicted to recognize rat SMAD1 Phospho (Ser463/Ser465) and SMAD9 Phospho (Ser465/Ser467) due to complete sequence homology between the immunizing peptide and each rat homolog.
Host
Mouse
Reactivity
Mouse, Human
Application
WB -Quality tested
Platform ID
BAB236886913
BioLegend
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Product Specifications
Scientific Background
Specifications
NamePurified anti-SMAD1 Phospho S463S465SMAD9 S465/S467 Antibody, SMAD1 Phospho, SMAD9 Phospho, A17019A
Cat. No.610402
HostMouse
RRIDAB_2801107 (BioLegend Cat. No. 610401)AB_2801108 (BioLegend Cat. No. 610402)
IsotypeMouse IgG1, λ
ReactivityMouse, Human
ApplicationWB -Quality tested
ClonalityMonoclonal
Clone NumberA17019A
Concentration0.5 mg/ml
TargetSMAD1 Phospho Ser463/Ser465 SMAD9 Phospho Ser465/Ser467
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
SMAD1 and SMAD9 (SMAD8) are members of SMAD family, whose members play a critical role in signal transduction from the TGF-β receptor kinases. Activation of these receptors results in phosphorylation of SMAD1 and SMAD9 at a C-terminal SSXS motif (Ser463/Ser465 in SMAD1; Ser465/Ser467 in SMAD9), leading to dimerization with the coactivator SMAD4. The SMAD1-4 complex is translocated to the nucleus where it induces expression of target genes involved in differentiation, self-renewal, proliferation, and apoptosis.
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