Purified anti-SMAD2 Antibody, SMAD2, 6H5-E3-C11,BioLegend,606452
Since SMAD2 shares a high percentage of identity with SMAD3, this clone recognizes both SMAD2 and SMAD3, which can be resolved by Western Blot.
Host
Mouse
Reactivity
Human, Mouse
Application
WB - Quality tested
Platform ID
BAB633186713
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePurified anti-SMAD2 Antibody, SMAD2, 6H5-E3-C11
Cat. No.606452
HostMouse
RRIDAB_2924617 (BioLegend Cat. No. 606451)AB_2924617 (BioLegend Cat. No. 606452)
IsotypeMouse IgG1, κ
ReactivityHuman, Mouse
ApplicationWB - Quality tested
ClonalityMonoclonal
Clone Number6H5-E3-C11
Concentration0.5 mg/mL
TargetSMAD2
ImmunogenRecombinant fragments of human SMAD2
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
SMAD2 is a potent regulator of different cellular processes such as apoptosis, differentiation, and cell proliferation. SMAD2 is associated with SARA protein and the TGF-B receptor. SMAD2 gets phosphorylated by the TGF-B receptor in response to TGF-B signal, which induces its dissociation from SARA and association with SMAD4 followed by translocation into the nucleus. In the nucleus, the SMAD2/SMAD4 protein participates in gene regulation by forming a transcription repressor complex in association with other cofactors.
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