Purified anti-SMC3 Antibody, SMC3, DJ5.2.3,BioLegend,605351
Product was tested for use in ICC and IHC-P applications but did not meet passing criteria.
Host
Mouse
Reactivity
Human, Mouse
Application
WB - Quality tested
Platform ID
BAB406150685
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePurified anti-SMC3 Antibody, SMC3, DJ5.2.3
Cat. No.605351
HostMouse
RRIDAB_2924611 (BioLegend Cat. No. 605351)AB_2924611 (BioLegend Cat. No. 605352)
IsotypeMouse IgG1, κ
ReactivityHuman, Mouse
ApplicationWB - Quality tested
ClonalityMonoclonal
Clone NumberDJ5.2.3
Concentration0.5 mg/mL
TargetSMC3
ImmunogenSynthetic fragment of X. laevis SMC3, raised from mice immunized with the peptide sequence: EEVSLRRVIGAKKDQYFLDKK, corresponding to amino acids 94 -114 of Xenopus laevis SMC3.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
Structural maintenance of chromosomes protein 3 (SMC3) is a member of the SMC protein family and a component of the cohesin complex. Cohesin plays an important role in mitosis and meiosis by mediating sister chromatid cohesion, homologous recombination, and spindle pole formation. SMC3 activity is mediated by phosphorylation at a pair of conserved lysine residues, stabilizing the cohesion complex during mitosis. Mutations in SMC3 can result in Cornelia de Lange syndrome, characterized by developmental disabilities.
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