Purified anti-SMC3 Antibody, SMC3, W23212B,BioLegend,648806

SMC3 (Structural Maintenance of Chromosomes 3) is a core component of the cohesin complex, a group of proteins essential for chromosome cohesion, segregation, DNA repair, and transcriptional regulation in eukaryotic cells. SMC3 belongs to the Structural Maintenance of Chromosomes (SMC) family of ATPases, which includes other members such as SMC1, SMC2, SMC4, SMC5, and SMC6. Together with SMC1A, RAD21 (SCC1), and STAG proteins (SA1/SA2), SMC3 forms the ring-shaped cohesin complex that topologically encircles sister chromatids, holding them together after DNA replication until their separation during mitosis or meiosis. SMC3 and the broader cohesin complex are involved in regulating gene expression through chromatin architecture remodeling. Cohesin interacts with CTCF (CCCTC-binding factor), a key architectural protein, to form chromatin loops and topologically associating domains (TADs). These structures bring enhancers and promoters into close proximity, modulating transcriptional programs necessary for development and differentiation.