Purified anti-Skp1 Antibody, Skp1, W18108A,BioLegend,669802
This clone recognizes human Skp1 and cross-reacts with mouse Skp1.When tested for WB, this clone detected a ~40 kDa protein of unknown origin; this band was not observed at lower antibody titrations.Because of the binding of this antibody to the unknown protein, this clone was not tested for ICC.This clone failed IP testing.
Host
Rat
Reactivity
Human, Mouse
Application
WB -Quality tested
Platform ID
BAB706340318
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePurified anti-Skp1 Antibody, Skp1, W18108A
Cat. No.669802
HostRat
RRIDAB_2820110 (BioLegend Cat. No. 669801)AB_2820111 (BioLegend Cat. No. 669802)
IsotypeRat IgG2a, κ
ReactivityHuman, Mouse
ApplicationWB -Quality tested
ClonalityMonoclonal
Clone NumberW18108A
Concentration0.5 mg/mL
TargetSkp1
ImmunogenFull length recombinant human Skp1 protein
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
S-phase kinase-associated protein 1 (Skp1) is one of the components of the SCF complex, which belongs to the E3 ubiquitin-protein ligase family. The SCF complex recruits substrates and promotes ubiquitin-mediated degradation of the substrates. Skp1 forms an invariable core component of the SCF complex with Cul1 and Rbx1 proteins. Skp1 binds to F-box proteins, which recruit the substrates for proteolysis.
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