Purified anti-Spastin Antibody, Spastin, Sp3G111,BioLegend,868201

Spastin is a microtubule-severing protein that cleaves longer microtubules (MTs) to shorter ones. The severing of MT regulates its numbers and mobility, and the distribution of the plus-end. This has also been related to membrane trafficking of microtubules. Mutations in the spastin geneSPG4is the main cause for hereditary spastic paraplegia, a neurodegenerative disorder mainly occurring in corticospinal tracks. Due to the presence of 2 start codons inSPG4gene, 2 isoforms of spastin exist: a 68 kD isoform termed M1 and a 60 kD isoform termed M87. The M1 isoform is only detected in the adult spinal cord while the M87 isoform is ubiquitously expressed.