Purified anti-Synaptobrevin VAMP Antibody, Synaptobrevin (VAMP), SP10,BioLegend,837004

SP10 reacts with native, denatured and recombinant synaptic vesicle proteins synaptobrevin/VAMP-1 (aa 1-118) and VAMP-2 expressed in a bacterial system (aa 33-96). The antibody is particularly valuable for immunocytochemical studies of the brain due to its stability in formalin sections.

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

WB -Quality testedIHC-P -VerifiedELISA, ICC -Reported in the literature, not verified in house

Platform ID

BAB155414774

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePurified anti-Synaptobrevin VAMP Antibody, Synaptobrevin (VAMP), SP10
Cat. No.837004
HostMouse
RRIDAB_2810717 (BioLegend Cat. No. 837003)AB_2810718 (BioLegend Cat. No. 837004)
IsotypeMouse IgG2b, κ
ReactivityHuman, Mouse, Rat
ApplicationWB -Quality testedIHC-P -VerifiedELISA, ICC -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberSP10
Concentration0.5 mg/mL
TargetSynaptobrevin
ImmunogenThis antibody was raised against a crude synaptic preparation of post mortem human brain.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Synaptobrevins, also known as VAMPs, along with syntaxins and the synaptosomal-associated protein SNAP25, form the protein complex that is involved with the docking and fusion of synaptic vesicles with the presynaptic membrane. Synaptobrevins have a molecular weight of 18 kD, and are also involved in the formation of the SNARE complexes. The synaptobrevins are degraded by the protein tetanospasmin, from the tetanus-causing bacteriumClostridium tetani, as well as botulinum toxin fromClostridium botulinum.

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