Purified anti-Synaptophysin Antibody, Synaptophysin, SP17,BioLegend,837104

SP17 reacts with native, denatured and recombinant synaptic vesicle protein synaptophysin expressed in CHO cells. The antibody is particularly valuable for immunocytochemical studies of the brain due to its stability in formalin sections.

Host

Mouse

Reactivity

Human, Mouse, Rat

Application

WB -Quality testedICC, IHC-P -VerifiedSB -Community verified

Platform ID

BAB030452256

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-Synaptophysin Antibody, Synaptophysin, SP17
Cat. No.837104
HostMouse
RRIDAB_2783410 (BioLegend Cat. No. 837103)AB_2783411 (BioLegend Cat. No. 837104)
IsotypeMouse IgM, κ
ReactivityHuman, Mouse, Rat
ApplicationWB -Quality testedICC, IHC-P -VerifiedSB -Community verified
ClonalityMonoclonal
Clone NumberSP17
Concentration0.5 mg/ml
TargetSynaptophysin
ImmunogenThis antibody was raised against a crude synaptic preparation from post mortem human brain.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Synaptophysin, also known as major synaptic vesicle protein P38, is encoded by the SYP gene in humans and is located on the short arm of the X chromosome. Synaptophysin is expressed in neuroendocrine cells as well as all neurons in the CNS that participate in synaptic transmission. Synaptophysin is a synaptic vesicle glycoprotein, and interacts with synaptobrevin. It has been implicated in X-linked mental retardation and can be used as a specific marker for cells of the adrenal medulla and pancreatic islets. As such, it can be used to identify tumors that are derived from those cells, including neuroblastoma, retinoblastoma, medulloblastoma, and others.

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