Purified anti-TFAM Antibody anti-TFAM - 18G102B2E11,BioLegend,850501

This antibody recognizes endogenous TFAM in human brain tissues in WB and IHC applications but does not recognize mouse TFAM.

Host

Mouse

Reactivity

Human

Application

WB -Quality testedIHC-P -Verified

Platform ID

BAB855924805

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-TFAM Antibody anti-TFAM - 18G102B2E11
Cat. No.850501
HostMouse
RRIDAB_2716009 (BioLegend Cat. No. 850501)AB_2716010 (BioLegend Cat. No. 850502)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationWB -Quality testedIHC-P -Verified
ClonalityMonoclonal
Clone Number18G102B2E11
Concentration0.5 mg/ml
TargetTFAM
ImmunogenFull-length human TFAM protein
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

TFAM (Transcription Factor A, Mitochondrial) binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation, and DNA replication and repair. The protein is required for accurate and efficient promoter recognition by mitochondrial RNA polymerase. Sequence polymorphisms in the TFAM gene are associated with Alzheimer's and Parkinson's diseases. Other diseases associated with TFAM include Mitochondrial DNA Depletion Syndrome, Hepatocerebral Form and Deoxyguanosine Kinase Deficiency.

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