Purified anti-TGM2 Antibody, TGM2, 4G3,BioLegend,641351

Protein-glutamine gamma-glutamyltransferase 2, also known as TGM2, is a multifunctional enzyme involved in various biological processes, including cell growth, differentiation, apoptosis, and tissue repair. It catalyzes protein crosslinking by bonding glutamine and lysine residues. It also functions as a deamidase, GTPase, and protein disulfide isomerase. In macrophages, TGM2 expression is induced by Th2 cytokines and plays an important role in M2 differentiation. These M2 macrophages are involved in anti-inflammatory responses, tissue repair, and remodeling. In addition, TGM2 helps in stabilizing the extracellular matrix and promoting cell adhesion, which are crucial for the proper functioning and differentiation of these macrophages. Dysregulation of TGM2 has been linked to several diseases, such as cancer, neurodegenerative disorders, and fibrosis. Overexpression of TGM2 is associated with tumor progression and chemoresistance, while its role in neurodegeneration involves the formation of protein aggregates.