Purified anti-TIF1γ/TRIM33 Antibody, TIF1γ/TRIM33, 3H7-C8-B9,BioLegend,611251

TIF1γ/TRIM33, belonging to the tripartite motif-containing (TIF) protein family, is a multifunctional protein that regulates hematopoiesis, DNA repair, mitosis, and transcription elongation. Just as with other TIF/TRIM family members, TIF1γ/TRIM33 contains a conservative RBCC/TRIM motif at the N terminus and a PHD/ bromodomain at the C terminus.  TIF1γ/TRIM33 suppresses the TGF-beta/BMP signaling pathway via monoubiquitylation of SMAD4 or the binding of phosphorylated SMAD2/3. Through its E3 ubiquitin ligase function, TIF1γ/TRIM33 decreases nuclear beta-catenin expression and suppresses tumorigenesis and tumor cell proliferation. TIF1γ/TRIM33’s tumor suppressive properties have been observed in hepatocellular carcinoma, chronic myelomonocytic leukemia, and pancreatic cancer. It has also been observed to reduce the stability of HIV-1 viral integrase to restrict HIV-1 infection.