Purified anti-TP63 Antibody anti-p63 - W15093A,BioLegend,687202

TP63 is a p53-related gene and shares similar domain organization with p53 and p73. Full length TP63 contains a N-terminal transactivation domain, a central DNA binding domain, and a C-terminal oligomerization domain responsible for the formation of a homotetramer. TP63 have several isoforms produced by alternative splicing. Most of the isoforms contain the DNA binding domain, but differ in their transactivation and oligomerization domains. The transactivation domain is present in the transcriptional active isoforms (TA-p63) and is absent in the truncated isoforms (ΔN -p63). TP63 is expressed in keratinocyte stem cells and is essential for the morphogenesis and development of ectodermal, orofacial, and limb tissues. TP63 deficient mice die soon after birth with skin and limb developmental defects.