Purified anti-TSC2 Antibody anti-TSC2 - W16104A,BioLegend,697701

Tuberous sclerosis 2 (TSC2) forms the tuberous sclerosis complex with TSC1 and functions as a crucial negative regulator of the Rheb/mTOR pathway. mTOR belongs to the PI3K-related kinase family and regulates protein translation, cell proliferation, and cell differentiation. Activation of mTOR requires binding to the active small GTPase Ras homolog enriched in brain (Rheb). TSC2 acts as a GTPase activating protein (GAP) and inhibits mTORC1 through converting active GTP-bound Rheb to inactive GDP-bound Rheb. Phosphorylation of TSC2 by AKT leads to inactivation of the tuberous sclerosis complex and in turn results in the activation of the Rheb/mTOR pathway. Mutations in the TSC2 gene lead to hyperactivation of the Rheb/mTOR pathway and are associated with the autosomal dominant disorder tuberous sclerosis and pulmonary lymphangioleiomyomatosis (LAM).