Purified anti-Tubulin alpha 8 Antibody anti-Tubulin alpha 8 - P82D6D7,BioLegend,691702

Clone P82D6D7 may also recognize the other Tubulin a members since this clone was developed with partial sequence of tubulin a 8 (a.a. 294-449) that shares high percentage of homology with other members in the Tubulin a family such as tubulin a 4A, tubulin a 3C/D, and tubulin a 1A.

Host

Mouse

Reactivity

Human

Application

WB -Quality testedICC -Verified

Platform ID

BAB015259552

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Product Specifications
Scientific Background

Specifications

NamePurified anti-Tubulin alpha 8 Antibody anti-Tubulin alpha 8 - P82D6D7
Cat. No.691702
HostMouse
RRIDAB_2632654 (BioLegend Cat. No. 691702)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationWB -Quality testedICC -Verified
ClonalityMonoclonal
Clone NumberP82D6D7
Concentration0.5 mg/ml
TargetTubulin alpha 8
ImmunogenPurified recombinant fragment of human Tubulin α 8 (a.a. 294-449) expressed inE. coli. This region shares high percentage of homology with other Tubulin α members.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Tubulin, one of the major constituents of microtubules, is a dimeric protein consisting of an alpha and beta tubulin. Tubulin is a highly conserved protein that is ubiquitously expressed. Tubulin is a GTP-binding protein that can be modified by phosphorylation and acetylation. Tubulin interacts with a variety of proteins including RAC GTPase activating protein 1, ZAP70, Polo-like kinase, c-Myc, Fyn, and microtubule associated protein 1A. Tubulin α 8 belongs to the Tubulin α family which contains 8 other members such as tubulin α 1A, tubulin α 4A, tubulin α 3E. It has been shown that mutations in the tubulin α 8 gene is associated with polymicrogyria and optic nerve hypoplasia.

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