Purified anti-VEGFR2 Phospho (Tyr1175) Antibody, VEGFR2 Phospho Tyr1175, Poly21A11,BioLegend,610051

This clone was tested for Western Blot on lysates from Huvec cells stimulated with or without VEGF-165.

Host

Rabbit

Reactivity

Human

Application

WB - Quality tested

Platform ID

BAB936374906

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NamePurified anti-VEGFR2 Phospho (Tyr1175) Antibody, VEGFR2 Phospho Tyr1175, Poly21A11
Cat. No.610051
HostRabbit
RRIDAB_2936689 (BioLegend Cat. No. 610051)AB_2936689 (BioLegend Cat. No. 610052)
IsotypeRabbit Polyclonal IgG
ReactivityHuman
ApplicationWB - Quality tested
ClonalityPolyclonal
Clone NumberPoly21A11
ConcentrationLot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in ourCertificate of Analysisonline tool.)
TargetVEGFR2
ImmunogenSynthetic peptide corresponding to human VEGFR2 phosphorylated at Tyrosine 1175
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

VEGFR2 is a tyrosine kinase receptor located in the cell surface. It serves as a receptor for VEGF-A, -E, -C, and -D. Interaction of VEGF and VEGFR2 induces dimerization of the receptor followed by transphosphorylation on its cytoplasmic domains. Phosphorylation sites include Tyr801, Tyr951, Tyr1054, Tyr1059, Tyr1175, Tyr1214, Tyr1223, Tyr1305, Tyr1309, and Tyr1319. Phosphorylation at the Tyr1175 residue facilitates binding for Phospholipase C-gamma (PLC-γ) and plays a critical role in signal transduction via MAP kinase pathway and DNA synthesis.

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.