Purified anti-VEGFR2 Phospho (Tyr951) Antibody, VEGFR2 Phospho Tyr951, Poly21A10,BioLegend,610151

VEGFR2 is a tyrosine kinase receptor located in the cell surface. It serves as a receptor for VEGF-A, -E, -C, and -D. Interaction of VEGF and VEGFR2 induces dimerization of the receptor followed by transphosphorylation on its cytoplasmic domains. Phosphorylation sites include Tyr801, Tyr951, Tyr1054, Tyr1059, Tyr1175, Tyr1214, Tyr1223, Tyr1305, Tyr1309, and Tyr1319. Phosphorylation at the Y951 residue facilitates binding to the SH2 domain of T-cell-specific adaptor (TSAd), which leads to activation of c-Src tyrosine kinase and vascular permeability.