Purified anti-XPC Antibody, XPC1, W20162C,BioLegend,604851

XPC is a protein involved in the nucleotide excision repair (NER) pathway, a mechanism that repairs single-stranded DNA damage. XPC is a member of the XPC complex that recognizes DNA damage resulting in thermodynamically unstable DNA structures. For example, the unstable structures caused by the damage from ultraviolet light. XPC-RAD23B activation recruits other NER pathway members to the site and promotes progression through NER. XPC mutations can result in the disease that is the protein’s namesake, Xeroderma pigmentosum, characterized by an extreme sensitivity to sunlight and high cancer risk. More broadly speaking, since DNA damage underlies many types of cancer, changes in XPC expression levels or mutations in XPC are often found in tumors.