Purified anti-YY1 Antibody, YY1, W21112E,BioLegend,621552

Clone is not recommended for ICC application.For IHC-P antigen retrieval with either Tris-EDTA, pH 6.0, or sodium citrate, pH 9.0 (e.g. Cat. No. 420901) is recommended.

Host

Rat

Reactivity

Human, Mouse

Application

WB - Quality testedIHC-P - Verified

Platform ID

BAB148806683

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

Email:

Product Specifications
Scientific Background

Specifications

NamePurified anti-YY1 Antibody, YY1, W21112E
Cat. No.621552
HostRat
RRIDAB_3083409 (BioLegend Cat. No. 621551)AB_3083409 (BioLegend Cat. No. 621552)
IsotypeRat IgG2a, κ
ReactivityHuman, Mouse
ApplicationWB - Quality testedIHC-P - Verified
ClonalityMonoclonal
Clone NumberW21112E
Concentration0.5 mg/mL
TargetYY1
ImmunogenRecombinant full-length human YY1 expressed inE.coli
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Yin Yang 1 (YY1), is a ubiquitously distributed transcription factor that plays a pivotal role in regulating gene expression and coordinating various cellular processes. By interacting with other transcription factors, co-regulators, and epigenetic modifiers, YY1 can modulate gene expression to control diverse biological processes, including cell proliferation, differentiation, apoptosis, and development. Based on its interactions with other proteins such as MYC, YY1 can function as a transcriptional activator or repressor. Furthermore, YY1 is involved in maintaining genomic stability and has been implicated in DNA repair mechanisms. Its ability to interact with a wide range of regulatory elements and its context-dependent transcriptional activities make YY1 an essential factor in orchestrating intricate gene regulatory networks within the cell, and a potential target for cancer therapies.

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