Purified anti-ZO-3 Antibody, ZO-3, W22143C,BioLegend,637651

ZO-3 is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family. Together with ZO-1 and ZO-2, they act as scaffold proteins that link transmembrane proteins in the tight junctions such as claudins, junctional adhesins and occludins to the actin cytoskeleton forming a boundary between the apical and basolateral plasma membrane on epithelial cells. The importance of this complex of proteins is to maintain tight junctions and limit the paracellular movement of substances. In addition, ZO-3 sequesters Cyclin D1 avoiding its degradation during mitosis and enabling S-phase transition. Celiac Disease 1 has been associated with ZO-3.