Purified anti-beta-Amyloid, 1-16 Antibody anti-beta-Amyloid - 6E10,BioLegend,803001

This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS).This antibody clone has been reported for use in immunohistochemistry of free-floating sections2,13.

Host

Mouse

Reactivity

Human

Application

WB -Quality testedDirect ELISA, IHC-P-VerifiedIHC-F, EM, ICC -Reported in the literature, not verified in house

Platform ID

BAB695368116

BioLegend

Headquarters

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePurified anti-beta-Amyloid, 1-16 Antibody anti-beta-Amyloid - 6E10
Cat. No.803001
HostMouse
RRIDAB_2715854 (BioLegend Cat. No. 803004)AB_2564653 (BioLegend Cat. No. 803001)AB_2564654 (BioLegend Cat. No. 803002)AB_2564652 (BioLegend Cat. No. 803003)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationWB -Quality testedDirect ELISA, IHC-P-VerifiedIHC-F, EM, ICC -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone Number60000000000
Concentration1 mg/mL
Targetbeta-Amyloid 1-16
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution (no preservatives or carrier proteins).
StorageThis antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label orCoAto find the proper storage conditions.
Regulatory StatusResearch Use Only

Scientific Background

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

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