Purified anti-beta-Tubulin Antibody anti-beta-Tubulin - O95C1,BioLegend,605101

Because of complete sequence homology, this clone is also predicted to recognize TUBB4A in higher eukaryotes, including rat, monkey, pig, bovine, and canine. This clone was generated using full-length recombinant TUBB4A as an immunogen. However, due to high sequence homology, this clone may also recognize other members of the ß-Tubulin family, notably TUBB2A, TUBB3, TUBB4B, and TUBB8. Because these ß-Tubulins have a similar molecular weight as TUBB4A, we do not recommend using this antibody as a TUBB4A-specific antibody. This clone was generated using a more defined immunogen (recombinant TUBB4A) than our existing ß-Tubulin clone, TU27/Tubulin (Cat. No. 903401), which was generated against taxol-assembled microtubules (mixed tubulins).

Host

Mouse

Reactivity

Mouse, Human

Application

WB -Quality tested

Platform ID

BAB949379925

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Product Specifications
Scientific Background

Specifications

NamePurified anti-beta-Tubulin Antibody anti-beta-Tubulin - O95C1
Cat. No.605101
HostMouse
RRIDAB_2728462 (BioLegend Cat. No. 605101)AB_2728463 (BioLegend Cat. No. 605102)
IsotypeMouse IgG2b, κ
ReactivityMouse, Human
ApplicationWB -Quality tested
ClonalityMonoclonal
Clone NumberO95C1
Concentration0.5 mg/ml
Targetbeta-Tubulin
ImmunogenFull length protein expressed in HEK293T cells transfected with human TUBB4 expression vector.
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

Eukaryotic microtubules are tubular polymers of tubulin that are a major component of the cytoskeleton. They play an essential role in diverse cellular functions, including migration, mitosis, and trafficking, and are also critical for normal development. β- and α-tubulins comprise the two core protein families that heterodimerize and assemble into each microtubule filament. There are multiple β- and α-tubulins isotypes, with each showing unique tumoral and tissue-specific distribution. TUBB4A is a β–tubulin primarily expressed in nervous tissue and moderate expression in testis. Mutations inTUBB4Acause hypermyelinating leukodystrophy-6 and autosomal dominant torsion dystonia -4.

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