Purified anti-human ALK Antibody, ALK, W16190A,BioLegend,611551
W16189A is not suitable for ICC, FC, and IHC-P.W16189A is weakly cross-reactive with mouse ALK in WB.
Host
Rat
Reactivity
Human
Application
WB - Quality tested
Platform ID
BAB641760067
BioLegend
Contact
Tel: 1-858-455-9588
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Product Specifications
Scientific Background
Specifications
NamePurified anti-human ALK Antibody, ALK, W16190A
Cat. No.611551
HostRat
RRIDAB_2941602 (BioLegend Cat. No. 611551)AB_2941602 (BioLegend Cat. No. 611552)
IsotypeRat IgG2a, κ
ReactivityHuman
ApplicationWB - Quality tested
ClonalityMonoclonal
Clone NumberW16190A
Concentration0.5 mg/mL
TargetALK
ImmunogenRecombinant fragment of human ALK
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
ALK is expressed widely in the central nervous system, where it plays important roles in neurogenesis and the development of the nervous system. ALK is a receptor tyrosine kinase that phosphorylates tyrosines on target proteins upon ligand binding (known ligands include pleiotrophin, midkine, FAM150A, and FAM150B). ALK was originally discovered in anaplastic large-cell lymphoma cells where a chromosomal translocation leads to constitutive activation of the ALK kinase domain, making ALK a target of inhibition in cancer therapies.
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