Purified anti-human CD144 VE-Cadherin Antibody anti-CD144 - BV9,BioLegend,348502
Clone BV9 has been shown to block VE-cadherin, causing a redistribution of VE-cadherin away from intracellular junctions.6This clone binds to EC3-EC4 region in the extracellular domain of human VE-cadherin.7Additional reported applications (for the relevant formats) include: Western Blotting1,2, immunofluorescence microscopy1,3, immunoprecipitation1,4, blocking angiogenesisin vitro4,5, inhibiting VE-cadherin reorganization4, and inducing endothelial cell apoptosis4.
Host
Mouse
Reactivity
Human
Application
FC - Quality testedICC - VerifiedWB, IP - Reported in the literature, not verified in house
Platform ID
BAB337172546
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
Email:
Specifications
Scientific Background
CD144, also known as VE-cadherin and cadherin-5, is a 140 kD glycoprotein which is composed of five extracellular cadherin repeats and a highly conserved cytoplasmic tail region. It is a calcium-dependent transmembrane cell-cell adhesion molecule localized at the intercellular boundaries of endothelial cells, hematopoietic stem cells, and perineurial cells. It functions as a classic cadherin by mediating homophilic adhesion and functions as a plasma membrane attachment site for the cytoskeleton. CD144 is thought to play a role in vascular development, permeability, and remodeling.
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