Purified anti-human CD146 Antibody anti-CD146 - P1H12,BioLegend,361001

Additional reported applications (for the relevant formats of this clone) include: Western blotting3and IHC1,5.Clone P1H12 cross-reacts to Dog2, 5.

Host

Mouse

Reactivity

Human

Application

FC -Quality testedIHC-F, WB -Reported in the literature, not verified in house

Platform ID

BAB014260032

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD146 Antibody anti-CD146 - P1H12
Cat. No.361001
HostMouse
RRIDAB_2562882 (BioLegend Cat. No. 361001)AB_2562883 (BioLegend Cat. No. 361002)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC -Quality testedIHC-F, WB -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberP1H12
Concentration0.5 mg/ml
TargetCD146
ImmunogenCultured human umbilical cells
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD146 is a 118 kD integral transmembrane glycoprotein that is also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.

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