Purified anti-human CD152 CTLA-4 Antibody anti-CD152 - A3.6B10.G1,BioLegend,525401

ELISA Capture:The purified A3.6B10.G1 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated L3D10 antibody (Cat. No. 349911) as the detection antibody and recombinant human CTLA-4 (Cat. No. 591909) as the standard.Note:For testing human soluble CTLA-4 in serum, plasma or cell culture supernatant, LEGEND MAX™ Human Soluble CTLA-4 ELISA Kit with Pre-coated Plates (Cat. No. 437407 & 437408) are specially developed and recommended.This clone has been tested in-house and determined to not be suitable for applications in immunohistochemistry of frozen or paraffin-embedded tissue sections (IHC-F or IHC-P).

Host

Mouse

Reactivity

Human

Application

ELISA Capture - Quality tested

Platform ID

BAB452739576

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Contact

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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD152 CTLA-4 Antibody anti-CD152 - A3.6B10.G1
Cat. No.525401
HostMouse
RRIDAB_2562988 (BioLegend Cat. No. 525401)AB_2563003 (BioLegend Cat. No. 525402)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationELISA Capture - Quality tested
ClonalityMonoclonal
Clone NumberA3.6B10.G1
Concentration0.5 mg/ml
TargetCD152
ImmunogenExtracellular domain of human CTLA-4 and human IgG1 Fc fusion protein
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152, is a protein that plays an important regulatory role in the immune system. CTLA-4 is expressed on the surface of helper T cells and transmits an inhibitory signal to T cells. Mutations in the CTLA-4 gene have been associated with various autoimmune diseases, such as systemic lupus erythematosus, insulin-dependent diabetes mellitus, and other autoimmune diseases.An identified novel transcript of the CTLA-4 gene that may represent a native soluble form of CTLA-4 (sCTLA-4) showed that eleven of twenty patients with autoimmune thyroid disease (ATD) had a high concentration of sCTLA-4, whereas only one of thirty apparently healthy volunteers contained measurable levels. sCTLA-4 immunoreactivity was inhibited by its binding to B7.1, suggesting that sCTLA-4 is a functional receptor. sCTLA-4 also plays a role in the initial immune response to infection of immune cells by HIV, along with the CD-1 pathway and others.

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