Purified anti-human CD171 (L1CAM) Antibody, CD171, A21047G,BioLegend,318209

CD171, also known as L1CAM or L1, is a 200-220 kD neuronal cell adhesion molecule and member of the L1 protein family. This transmembrane glycoprotein plays an important role in nervous system development, including neuron-neuron adhesion, signal transduction, axon guidance, cell migration and differentiation. Mutations in the CD171 gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. CD171 is also strongly implicated in treatment-resistant cancers.