Purified anti-human CD262 (DR5, TRAIL-R2),BioLegend,390704
Clone A21121I does not block the staining of reference clone DJR2-4 (7-8)Recombinant protein completely blocks the staining of test clone A21121I.
Host
Mouse
Reactivity
Human
Application
FC - Quality testedICC - Verified
Platform ID
BAB990959957
BioLegend
Contact
Tel: 1-858-455-9588
Fax: +49 (4131) 7023913
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Product Specifications
Scientific Background
Specifications
NamePurified anti-human CD262 (DR5, TRAIL-R2)
Cat. No.390704
HostMouse
RRIDAB_3662368 (BioLegend Cat. No. 390704)
IsotypeMouse IgG2a, κ
ReactivityHuman
ApplicationFC - Quality testedICC - Verified
ClonalityMonoclonal
Clone NumberA21121I
Concentration0.5 mg/mL
TargetCD262
ImmunogenRecombinant Human TNFRSF10B
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only
Scientific Background
DR5, also known as TRAIL-R2, TRICK2, KILLER, and CD262, is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B). It binds the cytotoxic ligand, TRAIL, and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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