Purified anti-human CD32 Antibody anti-CD32 - FUN-2,BioLegend,303202

Additional reported applications (for the relevant formats) include: immunohistochemical staining3of acetone-fixed frozen tissue sections.Clone FUN-2 recognizes both CD32A and CD32B.

Host

Mouse

Reactivity

Human

Application

FC -Quality testedIHC-F -Reported in the literature, not verified in house

Platform ID

BAB473629544

BioLegend

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Contact

Tel: 1-858-455-9588
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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD32 Antibody anti-CD32 - FUN-2
Cat. No.303202
HostMouse
RRIDAB_314333 (BioLegend Cat. No. 303201)AB_314334 (BioLegend Cat. No. 303202)
IsotypeMouse IgG2b, κ
ReactivityHuman
ApplicationFC -Quality testedIHC-F -Reported in the literature, not verified in house
ClonalityMonoclonal
Clone NumberFUN-2
Concentration0.5 mg/ml
TargetCD32
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD32 is a 40 kD polymorphic transmembrane glycoprotein also known as FcγRII and FCRII. It is an immunoglobulin superfamily member expressed on monocytes/macrophages, granulocytes, platelets and B cells. There are at least 6 isoforms of CD32 resulting from alternative mRNA splicing. CD32 mediates phagocytosis and oxidative burst in granulocytes, as well as platelet aggregation and immunomodulation. The extracellular domain of CD32 binds to polymeric and aggregated IgG and immune complexes, while the intracellular domain has been reported to associate with SHP-1 (B1 isoform).

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