Purified anti-human CD366 Tim-3 Antibody anti-CD366 - F38-2E2,BioLegend,345001

Additional reported applications (for relevant formats of this clone) include: costimulation1(clone 2E2 has been shown to enhance T-cell receptor mediated activation and cytokine secretion) and blocking2,3.

Host

Mouse

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB659474089

BioLegend

Headquarters

8999 BioLegend Way San Diego, CA 92121 United States

BioLegend

Contact

Tel: 1-858-455-9588
Fax: +49 (4131) 7023913

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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD366 Tim-3 Antibody anti-CD366 - F38-2E2
Cat. No.345001
HostMouse
RRIDAB_2116575 (BioLegend Cat. No. 345001)AB_2116574 (BioLegend Cat. No. 345002)
IsotypeMouse IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberF38-2E2
Concentration0.5 mg/ml
TargetCD366
ImmunogenHuman Tim-3 fusion protein
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

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