Purified anti-human CD54 Antibody, CD54, W21128D,BioLegend,300707

Flow cytometry testing showed that clone W21128D can block the binding of clones HA58 and HCD54 on target cells.

Host

Rat

Reactivity

Human

Application

FC - Quality tested

Platform ID

BAB898881647

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Contact

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Product Specifications
Scientific Background

Specifications

NamePurified anti-human CD54 Antibody, CD54, W21128D
Cat. No.300707
HostRat
RRIDAB_3683299 (BioLegend Cat. No. 300707)
IsotypeRat IgG1, κ
ReactivityHuman
ApplicationFC - Quality tested
ClonalityMonoclonal
Clone NumberW21128D
Concentration0.5 mg/mL
TargetCD54
ImmunogenTransfectant cells (aa28-480) and recombinant protein (aa28-480)
PurityThe antibody was purified by affinity chromatography.
FormulationPhosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
StorageThe antibody solution should be stored undiluted between 2°C and 8°C.
Regulatory StatusResearch Use Only

Scientific Background

CD54, also known as ICAM-1, is a 85-110 kD type I transmembrane protein. It is expressed on activated endothelial cells, high endothelial venules, T and B cells, monocytes/macrophages, granulocytes, and dendritic cells. The expression of ICAM-1 on the cell surface is potently upregulated by activation; a soluble form of ICAM-1 can be released from the cell surface. CD54 plays a role in cellular adhesion and is involved in inflammation and leukocyte extravasation. CD54 has also been shown to be the major cellular receptor for rhinovirus. ICAM-1 binds to CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), CD11c/CD18 (p150, 95) as well as hyaluronan and fibrinogen.

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